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Contraindicated (one)pentobarbital will decrease the extent or effect of lumacaftor/ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will minimize the extent or result of diclofenac by impacting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Mysterious.pentobarbital will lessen the extent or outcome of flurb